Implication of sperm RNAs in transgenerational inheritance of the effects of early trauma in mice : Nature Neuroscience : Nature Publishing Group

29 Apr

In this study, the authors show that the heritable behavioral and metabolic changes that are observed in rodents exposed to early life stress are mediated by changes in miRNA levels in the sperm of affected males. Injection of isolated RNA from the sperm of stressed males into donor fertilized oocytes is able to induce these phenotypic changes in the resulting offspring.



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